%0 Journal Article %T Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in combination with standard of care chemotherapy in primarily untreated chemo na£¿ve upper gi-adenocarcinomas with peritoneal seeding ¨C a phase II/III trial of the AIO/CAOGI/ACO %A Alfred K£¿nigsrainer %A Beate Rau %A Clemens Tempfer %A Ines Gockel %A Marc Reymond %A Matthias Schwarzbach %A Pompiliu Piso %A Salah-Eddin Al-Batran %A Stefan P. M£¿nig %A Thomas Kraus %A Thorsten Oliver Goetze %A Ulli Bankstahl %A Urs Pabst %A Wolf O. Bechstein %J Archive of "Pleura and Peritoneum". %D 2018 %R 10.1515/pp-2018-0113 %X Peritoneal metastasis is a common and dismal evolution of several gastrointestinal (GI) tumors, including gastric, colorectal, hepatobiliary, pancreatic, and other cancers. The therapy of peritoneal metastasis is largely palliative; with the aim of prolonging life and preserving its quality. In the meantime, a significant pharmacological advantage of intraperitoneal chemotherapy was documented in the preclinical model, and numerous clinical studies have delivered promising clinical results %K intraperitoneal therapy %K peritoneal carcinomatosis %K pressurized intraperitoneal aerosol chemotherapy (PIPAC) %K upper gastrointestinal cancer. %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404998/