%0 Journal Article
%T Early and Late Histological and Ultrastructural Findings in Resected Infantile Capillary Hemangiomas Following Treatment with Topical Beta-Blocker Timolol Maleate 0.5%
%A Bart Wagner
%A G£¿ran Darius Hildebrand
%A Hardeep S. Mudhar
%A Kanmin Xue
%A Zuzana Sipkova
%J Archive of "Ocular Oncology and Pathology".
%D 2018
%R 10.1159/000477411
%X Infantile capillary hemangiomas (IHs) affect approximately 4¨C5% of infants. The systemic nonselective ¦Â-adrenergic antagonist, propranolol, has become the standard first-line treatment for severe IHs. The topical ¦Â-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. Despite their therapeutic success and prevalent use, the mechanism of action of ¦Â-adrenergic antagonists in the treatment of IHs is not well understood
%K Infantile capillary hemangioma
%K Topical ¦Â-blocker
%K Topical timolol maleate 0.5%
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167667/