%0 Journal Article
%T The Expanding Role of MT1-MMP in Cancer Progression
%A Anna M. Knapinska
%A Gregg B. Fields
%J Archive of "Pharmaceuticals".
%D 2019
%R 10.3390/ph12020077
%X For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen. Proteomics has revealed a great array of MT1-MMP substrates, and MT1-MMP selective inhibitors have allowed for a more complete mapping of MT1-MMP biological functions. MT1-MMP has extensive sheddase activities, is both a positive and negative regulator of angiogenesis, can act intracellularly and as a transcription factor, and modulates immune responses. We presently examine the multi-faceted role of MT1-MMP in cancer, with a consideration of how the diversity of MT1-MMP behaviors impacts the application of MT1-MMP inhibitors
%K matrix metalloproteinase
%K extracellular matrix
%K cancer progression
%K immunosuppression
%K signal transduction
%K collagenolysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630478/