%0 Journal Article
%T Influence of ABCB1 and CYP3A5 gene polymorphisms on pharmacokinetics of apixaban in patients with atrial fibrillation and acute stroke
%A Alexander Valerevich Kryukov
%A Anastasia Vladislavovna Ryabova
%A Denis Anatolevich Andreev
%A Dmitry Alekseevich Sychev
%A Elena Anatolievna Grishina
%A Irina Andreevna Matsneva
%A Kristina Anatolievna Ryzhikova
%A Mark Alekseevich Loskutnikov
%A Olga Dmitrievna Konova
%A Pavel Olegovich Bochkov
%A Valeriy Valerevich Smirnov
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2018
%R 10.2147/PGPM.S157111
%X Difficulties in non-vitamin K anticoagulant (NOAC) administration in acute stroke can be associated with changes in pharmacokinetic parameters of NOAC such as biotransformation, distribution, and excretion. Therefore, obtaining data on pharmacokinetics of NOAC and factors that affect it may help develop algorithms for personalized use of this drug class in patients with acute cardioembolic stroke
%K cardioembolic stroke
%K atrial fibrillation
%K non-vitamin K anticoagulants
%K apixaban
%K pharmacokinetics
%K pharmacogenetics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868588/