%0 Journal Article
%T The impact of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) gene polymorphisms on dabigatran equilibrium peak concentration in patients after total knee arthroplasty
%A Aleksei Vladimirovich Kozlov
%A Alexander Nikolaevich Levanov
%A Dmitriy Alekseevich Sychev
%A Elena Anatolyevna Grishina
%A Galina Vladislavovna Ramenskaya
%A Karin Badavievich Mirzaev
%A Kristina Anatolyevna Ryzhikova
%A Mikhail Alekseevich Gavrilov
%A Natalia Pavlovna Denisenko
%A Pavel Olegovich Bochkov
%A Tanya Bogoslovsky
%A Tatiana Vladimirovna Shelekhova
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2018
%R 10.2147/PGPM.S169277
%X Non-vitamin K oral anticoagulants (NOACs) are commonly used for prophylaxis of venous thromboembolism (VTE) in orthopedic patients. Despite known safety and high potency of NOACs, potential interactions of NOACs with genetic polymorphisms are poorly understood. Dabigatran etexilate is one of the most commonly prescribed direct thrombin inhibitors for the prevention of VTE. The objectives of this study were to assess the effect of ABCB1 (rs1045642 and rs4148738) and CES1 (rs2244613) polymorphisms on dabigatran pharmacokinetics in patients after total knee arthroplasty
%K new oral anticoagulants
%K dabigatran
%K venous thromboembolism
%K ABCB1
%K CES1
%K pharmacogenetics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064159/