%0 Journal Article
%T Creating and validating a warfarin pharmacogenetic dosing algorithm for Colombian patients
%A Carlos Martin Restrepo
%A Carlos-Alberto Calder¨®n-Ospina
%A Clara Alvarado
%A Daniela Duarte
%A Dora Janeth Fonseca
%A Jubby Marcela Galvez
%A Nidia Pe£¿a
%A Nora Constanza Contreras
%A Paul Laissue
%A Ricardo A Cifuentes
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2018
%R 10.2147/PGPM.S170515
%X Warfarin is an oral anticoagulant associated with adverse reaction to drugs due to wide inter- and intra-individual dosage variability. Warfarin dosage has been related to non-genetic and genetic factors. CYP2C9 and VKORC1 gene polymorphisms affect warfarin metabolism and dosage. Due to the central role of populations¡¯ ethnical and genetic origin on warfarin dosage variability, novel algorithms for Latin American subgroups are necessary to establish safe anticoagulation therapy
%K genetic polymorphism
%K adverse drug reaction
%K gene frequency
%K anticoagulants
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198877/