%0 Journal Article
%T CYP2D6 genotype can help to predict effectiveness and safety during opioid treatment for chronic low back pain: results from a retrospective study in an Italian cohort
%A Antonio Mutti
%A Concetta Dagostino
%A Elena Bignami
%A Massimo Allegri
%A Ron HN van Schaik
%A Simona DĄŻAgnelli
%A Valerio Napolioni
%J Archive of "Pharmacogenomics and Personalized Medicine".
%D 2018
%R 10.2147/PGPM.S181334
%X Opioids are widely used for chronic low back pain (CLBP); however, it is still unclear how to predict their effectiveness and safety. Codeine, tramadol and oxycodone are metabolized by CYP/CYP450 2D6 (CYP2D6), a highly polymorphic enzyme linked to allele-specific related differences in metabolic activity
%K polymorphisms
%K pharmacogenetics
%K codeine
%K oxycodone
%K analgesic drugs
%K personalized medicine
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205525/