%0 Journal Article
%T The application of frequency-domain photoacoustics to temperature-dependent measurements of the Grščneisen parameter in lipids
%A Andreas Mandelis
%A Bahman Lashkari
%A Simon Liang
%A Sung Soo Sean Choi
%A Vasilis Ntziachristos
%J Archive of "Photoacoustics".
%D 2018
%R 10.1016/j.pacs.2018.07.005
%X The Grščneisen parameter is an essential factor in biomedical photoacoustic (PA) diagnostics. In most PA imaging applications, the variation of the Grščneisen parameter with tissue type is insignificant. This is not the case for PA imaging and characterization of lipids, as they have a very distinct Grščneisen parameter compared with other tissue types. One example of PA applications involving lipids is the imaging and characterization of atherosclerotic plaques. Intravascular photoacoustic (IVPA) imaging is a promising diagnostic tool that can evaluate both plaque severity and composition. The literature for IVPA has mainly focused on using the difference in absorption coefficients between plaque components and healthy arterial tissues. However, the Grščneisen parameters for lipids and their behavior with temperature have not been well established in the literature. In this study we employ frequency-domain photoacoustic measurements to estimate the Grščneisen parameter by virtue of the ability of this modality to independently measure both the absorption coefficient and the Grščneisen parameter through the use of the phase channel. The values of the Grščneisen parameters of some lipids are calculated as functions of temperature in the range 25šC45ŁżĄăC
%K Grščneisen parameter
%K Intravascular imaging
%K Ultrasound
%K Atherosclerosis
%K Frequency-domain biomedical photoacoustics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091231/