%0 Journal Article
%T Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
%A Baek Kim
%A Bijan Mahboubi
%A Mario Stevenson
%A Mark E. Sharkey
%A Timothy Plitnik
%J Archive of "Pathogens and Immunity".
%D 2018
%R 10.20411/pai.v3i2.263
%X Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that promotes proteasomal degradation of SAMHD1. It is unclear how HIV-1, which does not appear to harbor a SAMHD1 escape mechanism, is able to infect macrophages in the face of SAMHD1 restriction
%K HIV-1
%K macrophages
%K SAMHD1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333473/