%0 Journal Article
%T Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis
%A Karol Borys Tudrej
%A Ma£żgorzata Koz£żowska-Wojciechowska
%A Tomasz Piecha
%J Archive of "Therapeutic Advances in Urology".
%D 2019
%R 10.1177/1756287218818030
%X Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Identification of a novel mediator of bladder inflammation and pain could lead to emerging new therapeutic strategy and the first causative therapy
%K BPS/IC
%K inflammasome
%K NLRP3
%K OAB
%K sterile inflammation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329030/