%0 Journal Article
%T Safety and tolerability of intrathecal liposomal amphotericin
B (AmBisome) for cryptococcal meningitis:
a retrospective study in HIV-infected patients
%A Gerardo Alvarez-Uria
%A Himachandra N.B. Pujari
%A Jayaram Battula
%A Manoranjan Midde
%J Archive of "Therapeutic Advances in Infectious Disease".
%D 2018
%R 10.1177/2049936118782846
%X While mortality of HIV-related cryptococcal meningitis (CM) in developed countries is relatively low, in developing countries over half of patients die within 10£¿weeks. Current recommended therapies are often not suitable for resource-poor settings, and new shorter regimens are urgently needed. Intrathecal administration of liposomal amphotericin B (lAmB) has shown promising results in animal models. However, the safety and tolerability of intrathecal lAmB in humans are not well known
%K AIDS-related opportunistic infections
%K antifungal agents
%K injections
%K patient safety
%K poverty
%K spinal
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136115/