%0 Journal Article
%T Thermodynamic considerations in renal separation processes
%A David Glasser
%A David M. Rubin
%A Diane Hildebrandt
%A Robert H. Louw
%A Robyn F. R. Letts
%J Archive of "Theoretical Biology & Medical Modelling".
%D 2017
%R 10.1186/s12976-017-0048-7
%X Urine production in the kidney is generally thought to be an energy-intensive process requiring large amounts of metabolic activity to power active transport mechanisms. This study uses a thermodynamic analysis to evaluate the minimum work requirements for urine production in the human kidney and provide a new perspective on the energy costs of urine production. In this study, black-box models are used to compare the Gibbs energy inflow and outflow of the overall kidney and physiologically-based subsections in the kidney, to calculate the work of separation for urine production
%K Human kidney
%K Urine production
%K Separation work
%K Gibbs energy
%K Energy balance
%K Sensitivity analysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267413/