%0 Journal Article
%T Effects of intravenous oxycodone alone or in combination with naltrexone on measures of respiratory depression: a randomized placebo-controlled study
%A Almasa Bass
%A Bimal K. Malhotra
%A Gernot Wolfram
%A Kyle T. Matschke
%A Lynn R. Webster
%J Archive of "Therapeutic Advances in Drug Safety".
%D 2019
%R 10.1177/2042098618821274
%X Abuse of prescription opioids, particularly by intravenous (IV) administration, can cause respiratory depression and death. ALO-02, an abuse-deterrent opioid formulation, is designed to release sequestered naltrexone upon manipulation by crushing, thereby antagonizing the pharmacologic effects of oxycodone. This exploratory post-hoc analysis examined the effects of IV administration of simulated crushed ALO-02 on end-tidal carbon dioxide (EtCO2), a surrogate marker of respiratory depression
%K intravenous
%K opioid overdose
%K opioids
%K oxycodone
%K prescription opioid abuse
%K respiratory depression
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360639/