%0 Journal Article
%T The Differentiation of Soft Tissue Infiltration and Surrounding Edema in an
Animal Model of Malignant Bone Tumor: Evaluation by Dual-Energy CT
%A Haisong Chen
%A Jing Pang
%A Meng Jia
%A Qian Dong
%A Wenjian Xu
%A Yuan Zhang
%A Zengjie Wu
%J Archive of "Technology in Cancer Research & Treatment".
%D 2019
%R 10.1177/1533033819846842
%X To study the value of dual energy computed tomography in distinguishing soft tissue infiltration from surrounding soft tissue edema in rabbit malignant bone tumor, a malignant bone tumor model was established through implantation of VX2 tumor fragments into the tibiae of rabbits. Tumor adjacent soft tissues were divided into 3 areas according to pathology and computed tomography images. Computed tomography spectral curve slopes and iodine and water concentrations were assessed. Statistical analyses were performed using the Mann-Whitney U test and t test. The spectral curve of the soft tissue infiltration areas has a slope (1.30 ¡À 0.41) higher than that of the soft tissue edema areas (0.71 ¡À 0.23; P < .001). The iodine concentration in the soft tissue infiltration areas (8.56 ¡À 2.15) was higher than that in the in soft tissue edema areas (6.09 ¡À 1.02; P < .001). Water concentration was similar in the soft tissue infiltration areas (1033.86 ¡À 10.50) to that of the edema areas (1031.45 ¡À 12.83; P < .05). Spectral curve analysis and iodine¨Cwater concentration are helpful in the differentiation of bone tumor soft tissue infiltration and soft tissue edema
%K bone neoplasm
%K malignant
%K edema
%K dual energy CT
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492347/