%0 Journal Article
%T Substance-P Ameliorates Dextran Sodium Sulfate-Induced Intestinal Damage by Preserving Tissue Barrier Function
%A Dae Yeon Hwang
%A Hyun Sook Hong
%A Suna Kim
%J Archive of "Tissue Engineering and Regenerative Medicine".
%D 2018
%R 10.1007/s13770-017-0085-7
%X The effect of SP in DSS-induced intestine damages. Mice received the drinking water with 1.5% DSS for 7 days and SP was administrated to tail vein during the intake of DSS. A Experimental schedule for colitis induction and SP treatment. B Gross view of intestine tissue. C Quantification of colon length (cm). D Histological analysis was performed by H&E staining. E Crypt length was measured as a distance from the bottom to apical crypt using Image J program. F Collagen deposition was carried out using Masson¡¯s trichrome staining. Results are shown as mean values ¡À SD. n = 10/group, *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar: 50 ¦̀
%K Substance-P
%K Tight junction
%K Intestine
%K Inflammatory bowel disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171643/