%0 Journal Article
%T Molting in C. elegans
%A David S. Fay
%A Vladimir La£¿eti£¿
%J Archive of "Worm".
%D 2017
%R 10.1080/21624054.2017.1330246
%X Molting is an essential developmental process for the majority of animal species on Earth. During the molting process, which is a specialized form of extracellular matrix (ECM) remodeling, the old apical ECM, or cuticle, is replaced with a new one. Many of the genes and pathways identified as important for molting in nematodes are highly conserved in vertebrates and include regulators and components of vesicular trafficking, steroid-hormone signaling, developmental timers, and hedgehog-like signaling. In this review, we discuss what is known about molting, with a focus on studies in Caenorhabditis elegans. We also describe the key structural elements of the cuticle that must be released, newly synthesized, or remodeled for proper molting to occur
%K C. elegans
%K cuticle
%K extracellular matrix
%K intracellular trafficking
%K molting
%K signaling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501215/