%0 Journal Article
%T Current advances in the functional studies of fatty acids and fatty acid-derived lipids in C. elegans
%A Huanhu Zhu
%A Lu Ying
%J Archive of "Worm".
%D 2016
%R 10.1080/21624054.2016.1184814
%X Fatty acids and fatty acid-derived lipids (FAs/FADLs) play essential roles in many living organisms, including contributions to membrane structure and signaling transduction. Aberrant metabolism of FAs/FADLs often causes diseases and health problems. However, the detailed mechanistic studies of specific FAs/FADLs in vivo are limited. C. elegans has been an effective model system for FA/ FADL studies due to its powerful genetics and conserved lipid biosynthetic pathways. The recently developed high-throughput analytic tools also enable sophisticated profiling of lipids molecules in C. elegans, which is critical for understanding their specific functions. Here we review a subset of current advances in FA/FADL functional studies in C. elegans
%K aging
%K C. elegans
%K fatty acid
%K fatty acid-derived lipids
%K reproductive process
%K stress response
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022663/