%0 Journal Article
%T Time- and dose-dependent claudin contribution to biological functions: Lessons from claudin-1 in skin
%A Atsushi Tamura
%A Reitaro Tokumasu
%A Sachiko Tsukita
%J Archive of "Tissue Barriers".
%D 2017
%R 10.1080/21688370.2017.1336194
%X There are many types of biologic compartments in the body. Tight junctions (TJs) function to create a dynamic paracellular barrier to separate these compartments and maintain homeostasis. The TJ component claudin-1 is the major transmembrane protein responsible for forming the paracellular barrier in the epidermis; other claudins in the epidermis include claudin-3, -4, -12, -23 and -25. Accumulating evidence points to a relationship between claudin-1 and skin diseases; for example, a decrease in claudin-1 is reported in human atopic dermatitis. However, how claudin-1 directly or indirectly contributes to disease in the context of the paracellular barrier is poorly understood. We recently established several mouse lines in which the claudin-1 expression was systematically regulated, and showed that claudin-1 time- and dose-dependently regulates epidermis function and disease in vivo. In this commentary, we will discuss recent progress on this topic, including our latest findings, and remaining or newly arisen issues
%K atopic dermatitis
%K claudin
%K claudin-1
%K skin
%K tight junctions
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571777/