%0 Journal Article
%T Acute Myeloid Leukemia Acquiring Promyelocytic Leukemia-Retinoic Acid Receptor Alpha at Relapse
%A Hashem A. Ayyad
%A Ishan Patel
%A Michael J. Levitt
%A Mohammad A. Hossain
%A Mohammed Shariff
%A Peter J. Mencel
%A Ravneet Bajwa
%A Varsha Gupta
%J Archive of "World Journal of Oncology".
%D 2019
%R 10.14740/wjon1211
%X Acute promyelocytic leukemia (APL) is identified as the M3 subtype of acute myeloid leukemia (AML). APL is presently one of the most curable leukemias. We describe here a rare case of APL who presented as a relapsed disease after 1 year of chemotherapy for AML. The patient lacked t(15;17) at the initial presentation but was present later at the time of relapse. The patient attained a complete remission following treatment with all-trans retinoic acid (ATRA) and arsenic trioxide-based therapy. We discuss the possible mechanism behind secondary acquisition of promyelocytic leukemia/retinoic acid receptor alpha (PML-RARA) at relapse of AML. We also briefly discuss the clinical features, diagnosis and treatment of APL
%K Acute myeloid leukemia
%K All-trans retinoic acid
%K Acute promyelocytic leukemia
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615911/