%0 Journal Article
%T Synchronous Presence of EGFR, ALK Driver Mutations Along With PD L1 Overexpression in a Resected Early Stage Non-Small Cell Lung Cancer: A Case Report and Review of Literature
%A Adarsh Vennepureddy
%A Alisa Sokoloff
%A Nishitha Thumallapally
%A Sara Parylo
%A Uroosa Ibrahim
%J Archive of "World Journal of Oncology".
%D 2018
%R 10.14740/wjon1090e
%X Treatment of lung cancer has been revolutionized with development of drugs that target key driver mutations and immune checkpoints. Until recently, it was believed that these driver mutations are mutually exclusive. However, few reports have emerged citing the presence of both mutations either synchronously or metachronously. We describe a case report of lung adenocarcinoma harboring two driver mutations in the same tumor cells as well as exhibiting high PDL1 expression. We further discuss the possible association of these driver mutations with PDL1 expression
%K Lung cancer
%K Driver mutations
%K PDL1 expression
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942208/