%0 Journal Article
%T DNA Damage Repair (DDR) Mutations and the Utility of High-Risk Genetics Clinics in Metastatic Castration-Refractory Prostate Cancer (mCRPC)
%A Andrew W. Hahn
%A Jennie Vagher
%A Neeraj Agarwal
%A Neysi Anderson
%A Nityam Rathi
%A Samantha Greenberg
%J Archive of "World Journal of Oncology".
%D 2018
%R 10.14740/wjon1144w
%X Germline pathogenic variants (PVs) in DNA-repair genes have garnered increasing attention in metastatic prostate cancer, and more patients are having somatic and germline DNA testing performed. Interpretation of germline DNA testing is a novel challenge for many clinicians, and the results of germline DNA-repair gene testing have significant implications for men with advanced prostate cancer and their children and siblings. Here, we report the case of a man with metastatic castration-refractory prostate cancer and a pathogenic, germline BRCA2 variant. We discuss the significance of his referral to a high-risk genetics clinic and the unique targeted therapy that he responded to
%K Germline pathogenic variants
%K DNA damage repair genes
%K DNA damage repair mutations
%K PARP inhibitors
%K High-risk genetics clinic
%K Hereditary clinic
%K Metastatic castration-refractory prostate cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134990/