%0 Journal Article
%T miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis
%A Carlo Maria Croce
%A Caterina Vicentini
%A Chiara Braconi
%A Claudia Mescoli
%A Edoardo D'Angelo
%A Fabio Farinati
%A Fotios Loupakis
%A Giada Munari
%A Giovanni Lanza
%A Imerio Angriman
%A Marco Agostini
%A Marco Scarpa
%A Massimo Rugge
%A Matteo Fassan
%A Nicola Valeri
%A Pierluigi Gasparini
%A Renata D'Inc¨˘
%A Ri Cui
%A Roberta Gaf¨¤
%A Salvatore Pucciarelli
%A Sara Lonardi
%A Vincenza Guzzardo
%A Wendy L. Frankel
%J Archive of "Translational Oncology".
%D 2019
%R 10.1016/j.tranon.2018.10.013
%X miR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive and invasive colorectal lesions was investigated for miR-224 expression by qRT-PCR and in situ hybridization. The caspase-3 and caspase-7 status was also assessed and correlated to miR-224 dysregulation. miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. miR-224 targets caspase-3 and caspase-7 in colorectal cancer, and this inverse relation was already evident from the earliest phases of transformation in intestinal mucosa. The miR-224/caspases axis may represent an interesting field of study for innovative biomarkers/therapeutics for BRAF-mutated/DNA mismatch repair-deficient tumors
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240712/