%0 Journal Article
%T Manganese-Enhanced Magnetic Resonance Imaging for Detection and Characterization of Colorectal Cancers
%A Dan Han
%A Liang Wen
%A Liping He
%A Xinan Shi
%J Archive of "Tomography".
%D 2018
%R 10.18383/j.tom.2018.00008
%X Here, we investigated the diagnostic performance of manganese (Mn)-enhanced magnetic resonance imaging (MEMRI) in colorectal cancer (CRC). The ability of CRC cell lines SW620 and SW480 to uptake Mn was evaluated and compared with a normal colon cell using MEMRI. Subcutaneous xenografts in nude mice underwent MRI examination at tumor sizes of 5, 10, and 15 mm. Contrast enhancement was compared between gadolinium (Gd)- and Mn-enhanced MRI. SW620 and SW480 cell lines took up more Mn2+ than normal cells, resulting in 4.5 and 2 times greater T1 value shortening than normal cell using in vitro MEMRI (P < .001). Most xenografts (17/23) enhanced markedly on MEMRI. A heterogeneous enhancement pattern invariably noted whether Mn or Gd agents were administered, but tumors imaged using MEMRI showed a greater degree of enhancement with a larger extent of enhanced area than those imaged using Gd-enhanced MRI. The numbers of markedly Mn-enhanced cases were more in the 5-mm-size tumor group than in 10- or 15-mm-size tumor groups. Overall, MEMRI could enhance CRCs and it showed potential in detecting early small lesions and markedly enhancing tumors that had minimal Gd enhancement
%K magnetic resonance imaging
%K manganese-enhanced
%K colorectal cancer
%K detection
%K characterization
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127351/