%0 Journal Article
%T Elevated axonal membrane permeability and its correlation with motor deficits in an animal model of multiple sclerosis
%A Gary Leung
%A Jonathan Tang
%A Melissa Tully
%A Riyi Shi
%A Shengxi Wu
%J Archive of "Translational Neurodegeneration".
%D 2017
%R 10.1186/s40035-017-0075-7
%X It is increasingly clear that in addition to myelin disruption, axonal degeneration may also represent a key pathology in multiple sclerosis (MS). Hence, elucidating the mechanisms of axonal degeneration may not only enhance our understanding of the overall MS pathology, but also elucidate additional therapeutic targets. The objective of this study is assess the degree of axonal membrane disruption and its significance in motor deficits in EAE mice
%K Multiple sclerosis
%K EAE
%K Axonal membrane damage
%K Polyethylene glycol
%K Acrolein
%K Horseradish Peroxidase
%K Membrane permeability
%K Neurodegeneration
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331741/