%0 Journal Article %T Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art ¨C with Reflections on Present AIM Challenges %A Casimir A. Kulikowski %J Archive of "Yearbook of Medical Informatics". %D 2019 %R 10.1055/s-0039-1677895 %X Background : The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry and medical decision-making, and for consultation in the 1970¡¯s led to a major change in the paradigm that affected all of artificial intelligence (AI) research. Since then, AI has evolved, surviving several ¡°winters¡±, as it has oscillated between relying on expensive and hard-to-validate knowledge-based approaches, and the alternative of using machine learning methods for inferring classification rules from labelled datasets. In the past couple of decades, we are seeing a gradual but progressive intertwining of the two %K Artificial Intelligence in medicine %K medical decision-making %K clinical knowledge representation %K expert systems %K knowledge engineering %K scientific inquiry %K cognitive and brain science %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697545/