%0 Journal Article
%T A Case of Recurrent Pregnancy-Induced Adult Onset Familial Hemophagocytic Lymphohistiocytosis
%A Bassam Theodory
%A Bassam Yaghmour
%A George Yaghmour
%A Giridharan Ramsingh
%A John Hu
%A Lan Y. Wang
%A Maria Vergara-Lluri
%J Archive of "World Journal of Oncology".
%D 2018
%R 10.14740/wjon1145w
%X Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease primarily of children, characterized by a severe hyperinflammatory state. We describe a case of adult onset familial HLH with a novel exon 19, c.1607G>T (p.Arg536Leu) heterozygous mutation of the UNC13D gene in a 40-year-old woman who developed HLH during her first and second pregnancies, both episodes occurring during the first trimester. Our patient was treated successfully both times with HLH-94 protocol following spontaneous abortions and is currently in the process of getting a bone marrow transplant. We also discuss pregnancy as a potential trigger for late onset familial HLH
%K Hemophagocytic lymphohistiocytosis
%K Pregnancy
%K Familial
%K Adult
%K Mutation
%K Chemotherapy
%K Genetic
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134992/