%0 Journal Article
%T Developing pharmacogenetic screening methods for an emergent country: Vietnam
%A Christopher Vidal
%A Dinh Van Nguyen
%A Hieu Chi Chu
%A Sheryl van Nunen
%J Archive of "The World Allergy Organization Journal".
%D 2019
%R 10.1016/j.waojou.2019.100037
%X The finding of strong associations between certain human leukocyte antigen (HLA) genotypes and the development of severe cutaneous adverse drug reactions (SCARs), [for example, HLA-B*57:01 and abacavir (ABC), HLA-B*15:02 and carbamazepine (CBZ) and HLA-B*58:01 and allopurinol], has led to HLA screening being used to prevent SCARs. Screening has been shown to be of great benefit in a number of studies. Clinical translation from bench to bedside, however, depends upon the development of simple, rapid and cost-effective assays to detect these risk alleles. In highly populated developing countries such as Vietnam, where there is a high prevalence of HLA-B*15:02 and HLA-B*58:01 correlating with a high incidence of CBZ- and allopurinol-induced SCARs, the crucial factor in the implementation of comprehensive screening programs to detect these major risk HLA alleles is the availability of suitable assays
%K Severe cutaneous adverse drug reactions
%K SCARs
%K HLA
%K Real-time PCR
%K HLA typing
%K HLA screening
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558218/