%0 Journal Article
%T A transgenic monkey model for the study of human brain evolution
%A Bing Su
%A Lei Shi
%J Archive of "Zoological Research".
%D 2019
%R 10.24272/j.issn.2095-8137.2019.031
%X Why humans have large brains with higher cognitive abilities is a question long asked by scientists. However, much remains unknown, especially the underlying genetic mechanisms. With the use of a transgenic monkey model, we showed that human-specific sequence changes of a key brain development gene (Primary microcephaly 1, MCPH1) could result in detectable molecular and cognitive changes resembling human neoteny, a notable characteristic developed during human evolution. This study was published in National Science Review ( Shi et al., 2019)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591165/