%0 Journal Article
%T Synthesis of water-soluble fluorescent polymeric glycoconjugate for the detection of cholera toxin
%A Lijuan Feng
%A Min Wang
%A Mingjun Zhong
%A Qi Chen
%A Shizhen Zhang
%A Zhi-Yong Sun
%J Designed Monomers and Polymers
%D 2019
%R https://doi.org/10.1080/15685551.2019.1654695
%X ABSTRACT Considering inherence optical properties of adjoint polyfluorenes and special functions of water-soluble conjugated glycopolymers, a triazole chain glycoconjugate via one-pot method were rapidly synthesized to prepare a lactate ligand polyfluorene with a clear fluorescent label by a nickel-catalyzed Yamamoto coupling polymerization. The water solubility and biocompatibility of the glycoconjugated polymer were ameliorated when the lactose group introduced as the side chain of the conjugated polymer. As a fluorescent multivalent system of glycoconjugates containing pyranogalactose groups, the interaction between pyranogalactose group and cholera toxin B subunit was studied by fluorescence spectrophotometric titration. PF-Lac has a broad application prospect in the check of cholera toxin and the study of glycoprotein interaction
%U https://www.tandfonline.com/doi/full/10.1080/15685551.2019.1654695