%0 Journal Article
%T Association of the oral microbiome with the progression of impaired fasting glucose in a Chinese elderly population
%A Bao-Cheng Liu
%A Dong Li
%A Guang Ji
%A Lei Zhang
%A Li Zhang
%A Meng-Meng Ji
%A Qing Lang
%A Rui-Rui Wang
%A Yue-Song Xu
%J Journal of Oral Microbiology
%D 2019
%R https://doi.org/10.1080/20002297.2019.1605789
%X ABSTRACT Objective: The oral microbiota is associated with the risk of type 2 diabetes (T2D), but the relationship between the oral microbiota and disease progression in the elderly population remains to be determined. Design: In our study, we recruited 150 elderly Chinese residents and divided them into three groups according to their fasting glucose (FG) level: normal (N), high (H), and very high (VH). Their biochemical indexes were analyzed using blood samples. Saliva samples were collected and the oral microbiome was profiled by high-throughput sequencing of the V3-V4 area of the 16S rRNA gene. Result: Our results revealed that the VH group showed deterioration of the metabolic phenotype and dysbiosis of the oral microbiota simultaneously when compared to the other two groups. Furthermore, potential disease-associated bacterial genera including Leptotrichia, Staphylococcus, Catonella, and Bulleidia were significantly enriched in the VH group. Conclusions: These results suggest that dysbiosis of the oral microbiota may be a typical feature of hyperglycemia and might also contribute to disease aggravation in the progression of hyperglycemias
%U https://www.tandfonline.com/doi/full/10.1080/20002297.2019.1605789