%0 Journal Article
%T MiR-15b can target insulin receptor to regulate hepatic insulin signaling in mice
%A Jin-Rong Xia
%A Wei-Dong Li
%A Yan-Shu Lian
%J Animal Cells and Systems
%D 2019
%R https://doi.org/10.1080/19768354.2019.1583125
%X ABSTRACT Now diabetes is growing to be a health problems globally. However, its specific pathogenesis still needs further exploration. Here we showed that miR-15b was upregulated in the palmitate-induced HepG2 cells and livers of hyperglycemic mice. At the same time, we confirmed that the insulin receptor was a direct target of miR-15b. Then we found that the manipulation of miR-15b expression level could affect the insulin signaling pathway of HepG2 cells and the inhibition of miR-15b in liver of ob/ob mice can improve insulin sensitivity of mice. Furthermore, our study demonstrated that palmitate could upregulate the expression of miR-15b by activating PPAR¦Á. Our findings established PPAR¦Á-responsive miR-15b as a critical regulator of hepatic insulin signaling, thus serving as a new potential therapeutic target for diabetes
%U https://www.tandfonline.com/doi/full/10.1080/19768354.2019.1583125