%0 Journal Article
%T Efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma
%A Changfu Liu
%A Fei Cao
%A Haipeng Yu
%A Tongguo Si
%A Wenge Xing
%A Xueling Yang
%A Zhi Guo
%J International Journal of Hyperthermia
%D 2019
%R https://doi.org/10.1080/02656736.2018.1556819
%X Abstract Objective: To determine the safety and efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma. Material and methods: We conducted an observational study in 156 patients with advanced renal cell carcinoma unsuitable for surgical treatment. Participants received cryoablation£¿+£¿sorafenib (n£¿=£¿67) or sorafenib only (n£¿=£¿89). Objective response rate (ORR), disease control rate (DCR), progression-free survival time (PFS), overall survival (OS), change in immune function after treatment, rate of adverse events, and quality of life were compared between the two groups. Results: In the cryoablation£¿+£¿sorafenib group, ORR and DCR were significantly higher and PFS and OS were significantly longer than in the sorafenib only group (both p£¿<£¿.05). Immune function-related indicators were significantly improved after treatment in the cryoablation£¿+£¿sorafenib group (p£¿<£¿.05), but no significant difference was found between before and after treatment in the sorafenib only group (p£¿>£¿.05). The incidence of targeted drug-related side effects was not significantly different between the groups (p£¿>£¿.05), and cryoablation did not increase the risk of side effects of targeted drugs. Conclusion: Cryoablation combined with sorafenib had superior clinical efficacy compared with sorafenib-only for the treatment of advanced renal cell carcinoma unsuitable for surgical treatment. Moreover, this combined therapy may enhance the body¡¯s anti-tumor immunity and effectively prolong PFS and OS without compromising patient quality of life, thus representing a new treatment strategy for advanced renal cell carcinoma
%U https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1556819