%0 Journal Article
%T Lymphocytes upregulate CD36 in adipose tissue and liver
%A Alli M. Nuotio-Antar
%A Ashok Balasubramanyam
%A Dorothy E. Lewis
%A Gregory K. Wilkerson
%A Jacob Couturier
%A Jennifer M. Meyer
%A Jordan E. Lake
%A Juan Esquivel
%A K. Jagannadha Sastry
%A Lori R. Hill
%A Neeti Agarwal
%A Pradip Saha
%A Pramod N. Nehete
%A Ruth M. Ruprecht
%A Samir K. Lakhashe
%A Viraj Kulkarni
%J Adipocyte
%D 2019
%R https://doi.org/10.1080/21623945.2019.1609202
%X ABSTRACT CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5¨C40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation
%U https://www.tandfonline.com/doi/full/10.1080/21623945.2019.1609202