%0 Journal Article
%T Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin
%A Chi-Cheng Huang
%A Chi-Tang Ho
%A Chih-Hsiung Wu
%A Han-Chung Wu
%A Hang-Lung Chang
%A Hui-Wen Chang
%A Juo-Han Lin
%A Li-Ching Chen
%A Shih-Hsin Tu
%A Tzu-Chun Cheng
%A Wen-Jui Lee
%A Yuan-Soon Ho
%J Cell Adhesion & Migration
%D 2019
%R https://doi.org/10.1080/19336918.2019.1568139
%X ABSTRACT The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/¦Â-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, ¦Â-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration
%U https://www.tandfonline.com/doi/full/10.1080/19336918.2019.1568139