%0 Journal Article
%T Dual-target anti-Alzheimer¡¯s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity
%A Bing Gan
%A Changjun Zhang
%A Jianan Guo
%A Jing Su
%A Renren Bai
%A Sihang Yu
%A Tao Zhou
%A Xiaoying Jiang
%A Yuanyuan Xie
%A Zhisheng Mi
%J Journal of Enzyme Inhibition and Medicinal Chemistry
%D 2019
%R https://doi.org/10.1080/14756366.2019.1634703
%X Abstract MAO-B leads to an increase in the levels of hydrogen peroxide and oxidative free radicals, which contribute to the aetiology of the AD. Thus, both iron ion chelators and MAO-B inhibitors can be used to treat AD. Taking the coumarin derivatives and hydroxypyridinones as the lead compounds, a series of dual-target hybrids were designed and synthesised by Click Chemistry. The compounds were biologically evaluated for their iron ion chelating and MAO-B inhibitory activity. Most of the compounds displayed excellent iron ion chelating activity and moderate to good anti-MAO-B activity. Compounds 27b and 27j exhibited the most potent MAO-B inhibitory activity, with IC50 values of 0.68 and 0.86£¿¦ÌM, respectively. In summary, these dual-target compounds have the potential anti-AD activity
%U https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1634703