%0 Journal Article
%T Silicon-containing apatite fiber scaffolds with enhanced mechanical property express osteoinductivity and high osteoconductivity
%A H. Matsunari
%A H. Nagashima
%A K. Nakano
%A M. Aizawa
%A M. Honda
%A M. Nagaya
%A T. Inui
%A Y. Kinoshita
%A Y. Shigemitsu
%A Y. Yamada
%J Journal of Asian Ceramic Societies
%D 2019
%R https://doi.org/10.1080/21870764.2019.1595930
%X ABSTRACT We began this study by synthesizing apatite fibers (AFs) and silicon-containing apatite fibers (Si-AFs) using a homogeneous precipitation method. Next, we have successfully fabricated three-dimensional apatite fiber scaffolds (AFSs) and silicon-containing apatite fiber scaffolds (Si-AFSs) using the above the AFs and Si-AFs, respectively. Finally, we successfully enhanced the mechanical properties of the scaffolds using carbon beads (CBs) with diameters of 20 ¦Ìm and 150 ¦Ìm, and conducted uniaxial pressing of the green compacts. These were named ¡°AFS100,¡± ¡°AFS300,¡± ¡°Si-AFS100,¡± and ¡°Si-AFS300¡± based on the AF (or Si-AF)/CB ratio. In the study, these scaffolds with enhanced mechanical property were implanted into porcine tibia, muscle and fat, and their osteoconduction and osteoinduction were examined. The bone-formation rates of Si-AFS100 and Si-AFS300 were higher than those of AFS100 and AFS300, while the bone-formation rates of AFS100 and Si-AFS100, were higher than those of AFS300 and Si-AFS300. These results indicated that addition of Si and controlled porosity may promote osteoconduction. Furthermore, AFS100 and Si-AFS100 exhibited osteoinductivity in muscle in the absence of osteoblasts. In conclusion, Si-AFS100 with enhanced mechanical properties has high osteoconductivity and osteoinductivity and can be expected to be used as a scaffold material and next-generation artificial bone filler for promoting bone formation
%U https://www.tandfonline.com/doi/full/10.1080/21870764.2019.1595930