%0 Journal Article
%T Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study
%A Hamit Serdar Ba£¿bu£¿
%A Murat £¿lhan Atag¨¹n
%A Serhat Tun£¿
%A £¿zcan Erel
%J Psychiatry and Clinical Psychopharmacology
%D 2019
%R https://doi.org/10.1080/24750573.2019.1584489
%X ABSTRACT OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study. The patients with schizophrenia (n£¿=£¿36), bipolar disorder (n£¿=£¿37), major depression (n£¿=£¿40), and healthy control (n£¿=£¿32) were included in the study. All participants were initially evaluated by a clinical psychiatrist to confirm the appropriate diagnosis using the Structured Clinical Interview for Diagnostic and Statistical Manuel of Mental Disorders-IV (DSM-IV) Axis I Disorders (SCID-I). Serum copper level, ceruloplasmin mass, and ceruloplasmin-ferroxidase activity were measured. One-way ANOVA and Kruskal¨CWallis Tests were performed for statistical analyses. RESULTS: Serum ceruloplasmin-ferroxidase activity (¦Ö2 £¿=£¿9.11, p£¿=£¿0.028) demonstrated a significant statistical difference in all groups compared with the control group. Serum ceruloplasmin-ferroxidase activity of the bipolar disorder group was significantly higher than the healthy control group (p£¿=£¿0.012), major depression group (p£¿=£¿0.027), and the schizophrenia group (p£¿=£¿0.019). Erythrocyte sedimentation rate (ESR) (p£¿=£¿0.028) and waist circumference (p£¿=£¿0.005) in bipolar disorder group, and the C-reactive protein (CRP) (p£¿<£¿0.001) and cholesterol (p£¿=£¿0.043) in the schizophrenia group were found as the determinants of ceruloplasmin-ferroxidase activity. CONCLUSION: In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control. The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia. The ceruloplasmin-ferroxidase activity was correlated with erythrocyte sedimentation rate in the bipolar disorder group and with C-reactive protein in the schizophrenia group. Therefore, the ceruloplasmin-ferroxidase activity may be an encouraging candidate in the neuro-immune modulation and become a reliable clinical tool for demonstrating the strong association of inflammation in these disorders
%U https://www.tandfonline.com/doi/full/10.1080/24750573.2019.1584489