%0 Journal Article
%T Biological based Biosensor¡¯s Inception
%A Angelina Kasprowicz
%A Corentin Spriet
%A Jean-Fran£¿ois Bodart
%J Biosensors  Journal | Biomarkers Journal | Open Access Journal
%D 2016
%R 10.15226/2575-6303/1/1/00103
%X As an incipit, one has to define the term biosensor. The term has been enclosing several views and concepts, which we will not review here. Nevertheless, biological based biosensors can be common only defined as biological items, whose properties modifications upon environmental modifications can be measured. Herein this opinion article we will refer only to biosensors as the biological based ones, which cover [1] molecules : among the best characterized biosensors are the FRET (F£¿rster Resonance Energy Transfer)-based, genetically encoded Kinase Activity Reporter (KAR) [1,2], (2) cells : CBB (Cells Based Biosensors; [3] and (3) organisms, like Xenopus embryos, whose development is sensitive to external factors (FETAX), Frog Embryo Teratogenesis Assay Xenopus [4] (Figure 1A). The untangling of complex signalling network is imperative both for understanding cells and organisms physiological and pathological contexts, and for isolating the ideal property modifications to measure that will reflect, for example, the deregulation of these networks. These modifications are the one seeked for biosensors design or choice. Then, biosensors become mandatory for deciphering and characterizing molecular signatures associated with pathologies. The latter aspect is naturally tightly linked to prognosis and diagnosis
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