%0 Journal Article
%T Comparison of biochemical parameters among DPP4 inhibitor users and other oral hypoglycaemic drug users: a cross-sectional study from Anuradhapura, Sri Lanka
%A Channa & Agampodi
%A Devarajan
%A Jayasumana
%A Rathish
%A Suneth
%J The Journal of Health, Population and Nutrition
%D 2019
%X Background: Higher efficacy of incretin-based therapies for type 2 diabetes mellitus has been reported from Asia. Pancreatitis and hepatitis have also been suspected to occur due to dipeptidyl peptidase-4 inhibitor (DPP4I) treatment. The present study aims at comparing selected biochemical parameters among DPP4 inhibitor users and other oral hypoglycaemic drug users. Methods: Patients were recruited from the State Pharmaceutical Corporation, Anuradhapura, Sri Lanka, for a comparative cross-sectional study. Two groups were involved: ¡°DPP4I¡± user group ( n = 63) and ¡°other oral hypoglycaemic¡± user group ( n = 126). Mann-Whitney U test was performed to find a significant difference ( p < 0.05) in the distributions of HbA 1C, pancreatic amylase, serum lipase, AST and ALT levels between the two groups. Results: Contradicting to previous Asian studies, distribution of HbA1C ( p = 0.569) between anti-diabetic regimes with and without DPP4 inhibitors showed no significant difference. Also, amylase ( p = 0.171), AST ( p = 0.238) and ALT ( p = 0.347) failed to show significance. However, lipase was significantly ( p = 0.012) high in the DPP4I group. Conclusion: The study showed a significantly higher lipase level among the DPP4I users in comparison to other oral hypoglycaemic drug users, and possible reasons were discussed
%U http://www.bioline.org.br/abstract?id=hn19005&lang=en