%0 Journal Article
%T Construction of Virtual Neuron and Consolidation of Sleep and Memory Process¨C A Molecular Docking and Biomathematical Approach - Construction of Virtual Neuron and Consolidation of Sleep and Memory Process¨C A Molecular Docking and Biomathematical Approach - Open Access Pub
%A Bin Zhao
%A Jingfeng Tang
%A Jinming Cao
%A Kuiyun Huang
%A Xia Jiang
%J OAP | Home | Journal of Model Based Research | Open Access Pub
%D -1
%X DOI10.14302/issn.2643-2811.jmbr-19-2652 The relationship between sleep and memory never fails to fascinate human beings as we always keep curious about how the memory form and consolidate 1. Nevertheless, recent developments in molecular genetics, neurophysiology, and the cognitive neurosciences have produced a striking body of research that provides converging evidence for an important role of sleep in learning and the reprocessing of memories.Also, sleep deprivation has become a prevalent public health epidemic with a wide range of harmful consequences, including memory and cognitive impairment 2, some scientists tend to focus attention on the neurobiological root of this universal human experience. Previous Work Effects of sleep stage on consolidation early study of different sleep stages in memory consolidation in rats mainly focused on REM sleep (Random Eye Movement sleep) and the consequences of REMD (REM sleep deprivation) by repeatedly waking subjects at the first signs of REM sleep. All these memory tasks were typically emotionally loaded as it has been proved that REM sleep priority to improve the consolidation of memory emotions3, 4, and it turned out that REMD is only valid for a specific period of time after learning ¡ª the so-called "REM sleep window"5, 6. The first evidence of the causal role of SWS (Slow Wave Sleep) reactivation during memory consolidation comes from the study of human spatial location in the presence of odor7. Reactivation activates hippocampal memory redistribution to new cortical storage locations. On the other hand, another hypothesis, named ¡®sequential hypothesis¡¯, which argues that the best benefit of sleep for consolidating declarative and non-declarative memory occurs when SWS and REM sleep occur one after the other is also verified by the cross effect of SWS/REM on declarative/procedural memory consolidation8, 9. The Effects of Sleep/sleep Deprivation on Memory Sleep¡¯s Promotion on Memory Consolidation Sleep is characterized by the rapid occurrence of REM sleep and non-REM sleep, including slow wave sleep (SWS, Phases 3 and 4) and light sleep Phases 1 and 2 (see Figure 1, part a). . In Figure 1. Sleep structure and Electrophysiological sleep stage characteristics humans, the first part of the night (early sleep) is characterized by a high amount of SWS, while REM sleep is dominant in the lower half (late sleep). SWS and REM sleep are characterized by a specific pattern of electric field potential oscillations (see Figure 1, part In subsequent rapid eye movement (REM) sleep, the brain system operates in a
%U https://www.openaccesspub.org/jmbr/article/1044