%0 Journal Article
%T Flufenamic acid inhibits secondary hemorrhage and BSCB disruption after spinal cord injury
%A Dan Zhu
%A Jianyi Xu
%A Jiedong Wang
%A Tingting Yu
%A Yingtao Yao
%A Yiqiang Hu
%A Yongchao Wu
%A Zhilong Chen
%A Zhiyong Xiao
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25707
%X Acute spinal cord injury (SCI) induces secondary hemorrhage and initial blood-spinal cord barrier (BSCB) disruption. The transient receptor potential melastatin 4 (Trpm4) together with sulfonylurea receptor 1 (Sur1) forms the Sur1-Trpm4 channel complex. The up-regulation of Sur1-Trpm4 after injury plays a crucial role in secondary hemorrhage, which is the most destructive mechanism in secondary injuries of the central nervous system (CNS). The matrix metalloprotease (MMP)-mediated disruption of the BSCB leads to an inflammatory response, neurotoxin production and neuronal cell apoptosis. Thus, preventing secondary hemorrhage and BSCB disruption should be an important goal of therapeutic interventions in SCI.
%K spinal cord injury
%K secondary hemorrhage
%K blood-spinal cord barrier
%K Trpm4
%K matrix metalloproteases
%U http://www.thno.org/v08p4181.htm