%0 Journal Article
%T Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model
%A Bo Hai
%A Chunmei Zhang
%A Fei Liu
%A Jingsong Wang
%A Liang Hu
%A Linsha Ma
%A Lizheng Qin
%A Qingguo Zhao
%A Shimin Chang
%A Songlin Wang
%A Xiangchun Li
%A Xiaoshan Wu
%A Xiaoyu Feng
%A Yipu Xu
%A Zhao Zhu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26509
%X Irreversible hypofunction of salivary glands is common in head and neck cancer survivors treated with radiotherapy and can only be temporarily relieved with current treatments. We found recently in mouse models that transient activation of Hedgehog pathway following irradiation rescued salivary gland function by preserving salivary stem/progenitor cells, parasympathetic innervation and microvessels. Due to huge differences between salivary glands of rodents and humans, to examine the translational potential of this approach, we evaluated effects of Shh gene transfer in a miniature pig model of irradiation-induced hyposalivation.
%K hyposalivation
%K Hedgehog signaling
%K radiotherapy
%K gene therapy
%K pig model
%U http://www.thno.org/v08p4321.htm