%0 Journal Article
%T Rewiring of cisplatin-resistant bladder cancer cells through epigenetic regulation of genes involved in amino acid metabolism
%A Amit Gupta
%A Austin Yeon
%A Daniel J. Weisenberger
%A Gangning Liang
%A Jayoung Kim
%A Minhyung Kim
%A Myung Hee Park
%A Sungyong You
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.25130
%X Alterations in DNA methylation are important epigenetic markers in bladder cancer (BC). These epigenome modifications may drive the mechanisms of aggressive chemo-resistant BC. Clinicopathological biomarkers that indicate chemotherapeutic resistance are critical for better assessing treatment strategies for individual patients. Thus, in this study, we aimed to determine whether DNA methylation of certain metabolic enzymes is significantly altered in cisplatin-resistant BC cells.
%K SAT1
%K ASS1
%K cancer metabolism
%K metabolomics
%K DNA methylation
%K chromatin accessibility
%K cisplatin resistance
%U http://www.thno.org/v08p4520.htm