%0 Journal Article
%T Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
%A Dae Hwan Shin
%A Dong Ju Son
%A Jae-Kyung Jung
%A Jaesuk Yun
%A Jeong Soon Choi
%A Ji Young Kim
%A Jin Tae Hong
%A Ju Kyung Song
%A Ki Cheon Kim
%A Sang-Bae Han
%A Sin Kook Kang
%A Sun Young Kim
%A Yoon-Seok Roh
%A Yu Ri Kim
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.26467
%X Rationale: Chitinase 3-like 1 (Chi3L1) protein is up-regulated in various diseases including solid cancers. According to Genome-Wide Association Study (GWAS)/Online Mendelian Inheritance in Man (OMIM)/Differentially Expressed Gene (DEG) analyses, Chi3L1 is associated with 38 cancers, and more highly associated with cancer compared to other oncogenes such as EGFR, TNF¦Á, etc. However, the mechanisms and pathways by which Chi3L1 is associated with cancer are not clear. In current study, we investigated the role of Chi3L1 in lung metastasis.
%K Chi3L1
%K lung cancer
%K metastasis
%K USF1
%K miRNA 125a-3p
%U http://www.thno.org/v08p4409.htm