%0 Journal Article
%T Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system
%A Liping Tang
%A Samuel Achilefu
%A Siwen Li
%A Yalan Rui
%A Yueqing Gu
%A Yuxi Liu
%J Theranostics
%D 2018
%I Ivyspring International Publisher
%R 10.7150/thno.24469
%X Although EML4-ALK transforming fusion gene is represented in only 8% of non-small cell lung cancer (NSCLC) cases, its expression is partly responsive for the failure of current NSCLC treatments. Preventing secondary mutation of the ALK protein through direct gene manipulation could overcome NSCLC drug resistance.
%K EML4-ALK
%K gold nanoshell
%K gene therapy
%K hyperthermia
%K chemo-therapy.
%U http://www.thno.org/v08p2621.htm