%0 Journal Article
%T The role of E2F transcription factors family in Urothelial Carcinoma
%A Athanasios Kotsinas
%A Christos Alamanis
%A Georgia Pantelopoulou
%A Ioannis Adamakis
%A Kalliopi Kostelidou
%J Oncomedicine
%D 2018
%R 10.7150/oncm.22098
%X E2F transcription factor family is a group of 8 proteins that interact with pocket proteins and bind to target DNA in order to modulate cell cycle progression. Thus, their role is pivotal to cancer development and progression. Bladder cancer, a prominent cancer that affects both sexes, is also affected by E2F. E2F-1, E2F-3 and E2F-4 and -5 have a distinct impact on bladder development, progress and prognosis. However the role of the remaining E2Fs remains obscure, awaiting newer data that could provide useful therapeutic targets.
%K E2F transcription factor
%K cancer
%K bladder
%K apoptosis
%K regulation
%U http://www.oncm.org/v03p0110.htm