%0 Journal Article
%T Immunological Role of Vitamin D in Skin Diseases and Carcinoma
%A Chikezie O. Madu
%A Kelley Yuan
%A Yi Lu
%J Oncomedicine
%D 2017
%R 10.7150/oncm.19262
%X Growing evidence attests to the vital role vitamin D plays in the dynamics of the immune system. Active 1,25(OH)2D3 binds to the vitamin D receptor (VDR) to form a ligand-activated receptor complex able to control transcription in the nucleus. We examined the various mechanisms through which vitamin D3 alters and enhances immune responses in a variety of skin conditions, as well as the pathways it activates to inhibit the progression of tumors and carcinomas. The hormone primarily elicits a change as either an inflammation modulator or cancer suppressor. Also addressed are current advancements in vitamin D treatment methods through the development of novel analogs.
%K Vitamin D
%K Skin Diseases
%K Carcinoma
%U http://www.oncm.org/v02p0052.htm