%0 Journal Article
%T Deciphering Elevated Microsatellite Alterations at Selected Tetra/Pentanucleotide Repeats, Microsatellite Instability, and Loss of Heterozygosity in Colorectal Cancers
%A Chanjuan Shi
%A Cindy L. Vnencak-Jones
%A Justin M. Cates
%A Yang Wang
%J The Journal of Molecular Diagnostics
%D 2018
%R 10.1016/j.jmoldx.2018.02.001
%X Elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) are
common in colorectal cancers (CRCs). The association between EMAST and classic mono/dinucleotide
microsatellite instability (MSI) is unknown. We assessed the stability of 13 tetranucleotide
and three pentanucleotide repeat markers in tumor and normal tissue from 22 MSI-high
and 107 microsatellite-stable CRC samples. When present, instability was observed
at tetra/pentanucleotide repeats and was defined as elevated microsatellite alterations
at selected tetra/pentanucleotide repeats¨Chigh (EMASTP-H; ¡Ý30% instability), ¨Clow
(EMASTP-L; <30% instability), or ¨Cstable (EMASTP-S).
%U https://jmd.amjpathol.org/article/S1525-1578(17)30446-4/fulltext