%0 Journal Article
%T Lower perinatal exposure to Proteobacteria is an independent predictor of early childhood wheezing
%A Augusto A. Litonjua
%A Benjamin A. Turturice
%A David L. Perkins
%A Diane R. Gold
%A Emily Oken
%A Patricia W. Finn
%A Sheryl Rifas-Shiman
%J Journal of Allergy and Clinical Immunology
%D 2019
%R 10.1016/j.jaci.2018.06.051
%X We postulated that perinatal risk factors for asthma would be associated with early
exposure to bacteria or bacterial products. To evaluate this hypothesis, we assessed
circulating-free bacterial DNA (cfbDNA) in umbilical cord blood from mother-child
pairs (see Table E1 in this article's Online Repository at www.jacionline.org) from
Project Viva, a longitudinal study from birth through childhood.1 To assess cfbDNA,
we used 16s rRNA sequencing of the V1-3 region from circulating DNA isolated from
umbilical cord blood serum.
%U https://www.jacionline.org/article/S0091-6749(18)31277-6/abstract