%0 Journal Article
%T Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer
%A Pascale Quatresooz
%A Trinh Hermanns-L¨º
%A G¨¦rald E. Pi¨¦rard
%A Philippe Humbert
%A Philippe Delvenne
%A Claudine Pi¨¦rard-Franchimont
%J Journal of Biomedicine and Biotechnology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/147413
%X Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities. The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells. There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit. This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques. Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling. Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.
%U http://www.hindawi.com/journals/biomed/2012/147413/